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Major pharmaceutical company to cut nearly 250 Massachusetts jobs

The layoffs by Cambridge-based Takeda, affecting its Kendall Square workforce, are part of a restructuring plan to save $1.25 billion annually by 2028.

The Takeda Pharmaceutical Co. headquarters in Tokyo, Japan, on Monday, Oct. 31, 2022. Kiyoshi Ota

Takeda is planning its latest round of layoffs in Cambridge. Nearly 250 Massachusetts employees are expected to be affected as part of a broader restructuring plan.

A notice filed with the state says the cuts involve workers at Takeda’s 500 Kendall St. location. The layoffs are expected to begin in July, with some separations extending later into 2026 and into 2027.

The layoffs are part of a transformation plan approved by Takeda’s board on March 25. In a company announcement, Takeda said the effort is expected to generate more than 200 billion Japanese yen in annualized savings by fiscal 2028, or about $1.25 billion. The company said the plan is aimed at simplifying operations and shifting resources as it prepares for several expected product launches.

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“Today, Takeda is setting the stage to make a greater impact on the lives of patients as we prepare to launch multiple new medicines and continue to deliver on the promise of our pipeline,” CEO-elect Julie Kim said in the announcement. She added that the company’s “deliberate steps” are intended to help Takeda move faster and position itself for long-term growth.

The latest layoffs continue a series of pullbacks by the biopharma giant, which has its U.S. base in Massachusetts. The Boston Globe reported that Takeda announced a major restructuring effort in 2024 that included hundreds of Massachusetts layoffs. The Globe also reported that Takeda cut Cambridge jobs last year after ending its cell therapy work.

Takeda has also been reshaping its physical footprint in Cambridge. Fierce Biotech reported in February that the company had put more than 630,000 square feet on the sublease market. The move comes as Takeda shifts to a new research and development hub at 585 Kendall St., which is expected to open later this year.

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Takeda is not the only life sciences company making cuts in Massachusetts. The Boston Globe reported that Moderna and Thermo Fisher Scientific have also announced layoffs in the state in recent months.


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